MovDisordV3, Main, Exploration, bibRecord, 000D39

Is alpha-synuclein in the colon a biomarker for premotor Parkinson's disease? Evidence from 3 cases.

Identifieur interne : 000D39 ( Main/Exploration ); précédent : 000D38; suivant : 000D40

Is alpha-synuclein in the colon a biomarker for premotor Parkinson's disease? Evidence from 3 cases.

Auteurs : Kathleen M. Shannon [États-Unis] ; Ali Keshavarzian ; Hemraj B. Dodiya ; Shriram Jakate ; Jeffrey H. Kordower

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2012.

RBID : pubmed:22550057

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Biological Markers (metabolism), Colon (metabolism), Colon (pathology), Female, Humans, Male, Middle Aged, Neurites (metabolism), Neurites (pathology), Parkinson Disease (diagnosis), Parkinson Disease (metabolism), Parkinson Disease (pathology), Substance P (metabolism), alpha-Synuclein (metabolism).
MESH :
- chemical , metabolism : Biological Markers, Substance P, alpha-Synuclein.
- diagnosis : Parkinson Disease.
- metabolism : Colon, Neurites, Parkinson Disease.
- pathology : Colon, Neurites, Parkinson Disease.
- Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged.

Abstract

Despite clinicopathological evidence that Parkinson's disease (PD) may begin in peripheral tissues, identification of premotor Parkinson's disease is not yet possible. Alpha-synuclein aggregation underlies Parkinson's disease pathology, and its presence in peripheral tissues may be a reliable disease biomarker.

DOI: 10.1002/mds.25020
PubMed: 22550057

Affiliations:

États-Unis

Le document en format XML

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<author><name sortKey="Shannon, Kathleen M" sort="Shannon, Kathleen M" uniqKey="Shannon K" first="Kathleen M" last="Shannon">Kathleen M. Shannon</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurological Sciences, Rush Medical College, Chicago, Illinois 60612, USA. Kathleen_M_Shannon@rush.edu</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurological Sciences, Rush Medical College, Chicago, Illinois 60612</wicri:regionArea>
<wicri:noRegion>Illinois 60612</wicri:noRegion>
</affiliation>
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<author><name sortKey="Keshavarzian, Ali" sort="Keshavarzian, Ali" uniqKey="Keshavarzian A" first="Ali" last="Keshavarzian">Ali Keshavarzian</name>
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<author><name sortKey="Dodiya, Hemraj B" sort="Dodiya, Hemraj B" uniqKey="Dodiya H" first="Hemraj B" last="Dodiya">Hemraj B. Dodiya</name>
</author>
<author><name sortKey="Jakate, Shriram" sort="Jakate, Shriram" uniqKey="Jakate S" first="Shriram" last="Jakate">Shriram Jakate</name>
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<author><name sortKey="Kordower, Jeffrey H" sort="Kordower, Jeffrey H" uniqKey="Kordower J" first="Jeffrey H" last="Kordower">Jeffrey H. Kordower</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Is alpha-synuclein in the colon a biomarker for premotor Parkinson's disease? Evidence from 3 cases.</title>
<author><name sortKey="Shannon, Kathleen M" sort="Shannon, Kathleen M" uniqKey="Shannon K" first="Kathleen M" last="Shannon">Kathleen M. Shannon</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurological Sciences, Rush Medical College, Chicago, Illinois 60612, USA. Kathleen_M_Shannon@rush.edu</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurological Sciences, Rush Medical College, Chicago, Illinois 60612</wicri:regionArea>
<wicri:noRegion>Illinois 60612</wicri:noRegion>
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<author><name sortKey="Keshavarzian, Ali" sort="Keshavarzian, Ali" uniqKey="Keshavarzian A" first="Ali" last="Keshavarzian">Ali Keshavarzian</name>
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<author><name sortKey="Dodiya, Hemraj B" sort="Dodiya, Hemraj B" uniqKey="Dodiya H" first="Hemraj B" last="Dodiya">Hemraj B. Dodiya</name>
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<author><name sortKey="Jakate, Shriram" sort="Jakate, Shriram" uniqKey="Jakate S" first="Shriram" last="Jakate">Shriram Jakate</name>
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<author><name sortKey="Kordower, Jeffrey H" sort="Kordower, Jeffrey H" uniqKey="Kordower J" first="Jeffrey H" last="Kordower">Jeffrey H. Kordower</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2012" type="published">2012</date>
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<term>Aged, 80 and over</term>
<term>Biological Markers (metabolism)</term>
<term>Colon (metabolism)</term>
<term>Colon (pathology)</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neurites (metabolism)</term>
<term>Neurites (pathology)</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Parkinson Disease (metabolism)</term>
<term>Parkinson Disease (pathology)</term>
<term>Substance P (metabolism)</term>
<term>alpha-Synuclein (metabolism)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Biological Markers</term>
<term>Substance P</term>
<term>alpha-Synuclein</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Colon</term>
<term>Neurites</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Colon</term>
<term>Neurites</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
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<front><div type="abstract" xml:lang="en">Despite clinicopathological evidence that Parkinson's disease (PD) may begin in peripheral tissues, identification of premotor Parkinson's disease is not yet possible. Alpha-synuclein aggregation underlies Parkinson's disease pathology, and its presence in peripheral tissues may be a reliable disease biomarker.</div>
</front>
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<affiliations><list><country><li>États-Unis</li>
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<tree><noCountry><name sortKey="Dodiya, Hemraj B" sort="Dodiya, Hemraj B" uniqKey="Dodiya H" first="Hemraj B" last="Dodiya">Hemraj B. Dodiya</name>
<name sortKey="Jakate, Shriram" sort="Jakate, Shriram" uniqKey="Jakate S" first="Shriram" last="Jakate">Shriram Jakate</name>
<name sortKey="Keshavarzian, Ali" sort="Keshavarzian, Ali" uniqKey="Keshavarzian A" first="Ali" last="Keshavarzian">Ali Keshavarzian</name>
<name sortKey="Kordower, Jeffrey H" sort="Kordower, Jeffrey H" uniqKey="Kordower J" first="Jeffrey H" last="Kordower">Jeffrey H. Kordower</name>
</noCountry>
<country name="États-Unis"><noRegion><name sortKey="Shannon, Kathleen M" sort="Shannon, Kathleen M" uniqKey="Shannon K" first="Kathleen M" last="Shannon">Kathleen M. Shannon</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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Movement Disorders (revue)

Is alpha-synuclein in the colon a biomarker for premotor Parkinson's disease? Evidence from 3 cases.

Is alpha-synuclein in the colon a biomarker for premotor Parkinson's disease? Evidence from 3 cases.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.